David Comnenos1 
From 1203 to 1204 he invaded Trebizond with his brother Alexius.1 He conquered Paphlagonia.1
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 173. Hereinafter cited as “Genealogy of Trebizond.”
unknown daughter Comnene1
Children of unknown daughter Comnene and Alexios I Comnenos, Emperor of Trebizond
Ioannes Comnenos1 
Ioannes Comnenos also went by the nick-name of Ioannes ‘the Fat’.1
Child of Ioannes Comnenos and unknown daughter Comnene
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 174. Hereinafter cited as “Genealogy of Trebizond.”
Alexios Axouch1
Child of Alexios Axouch
- Ioannes Comnenos+1 d. 1200
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 174. Hereinafter cited as “Genealogy of Trebizond.”
unknown daughter Comnene1
Child of unknown daughter Comnene and Ioannes Comnenos
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 174. Hereinafter cited as “Genealogy of Trebizond.”
Anna Xylaloë1 
Child of Anna Xylaloë and Manuel I Comnenos, Emperor of Trebizond
- Andronikos II Comnenos, Emperor of Trebizond1 b. c 1240, d. 1266
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 174. Hereinafter cited as “Genealogy of Trebizond.”
Rusudan (?)1 
Child of Rusudan (?) and Manuel I Comnenos, Emperor of Trebizond
- Theodora Comnene, Empress of Trebizond1 b. bt 1242 – 1253
- [S151] Kelsey Jackson Williams, “A Genealogy of the Grand Komnenoi of Trebizond”, Jornal of Foundation for Medieval Genealogy 2.3 (January 2007): page 174. Hereinafter cited as “Genealogy of Trebizond.”
Eirene Syrikaina1
Children of Eirene Syrikaina and Manuel I Comnenos, Emperor of Trebizond
- unknown daughter1 Comnene+2 d. a 1298
- unknown daughter2 Comnene2
- Georgios Comnenos, Emperor of Trebizond1 b. a 1253, d. a 1280
- Ioannes II Comnenos, Emperor of Trebizond+2 b. c 1262, d. 16 Aug 1297
